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<meta name="DC.Title" content="3D Enhancement Color Maps in the Characterization of Intracranial Atherosclerotic Plaques" />
<meta name="DC.Identifier" content="10.3174/ajnr.A7605" />
<meta name="DC.Date" content="2022-09-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: High-resolution MR imaging allows the identification of culprit symptomatic plaques after the administration of gadolinium. Current high-resolution MR imaging methods are limited by 2D multiplanar views and manual sampling of ROIs. We analyzed a new 3D method to objectively quantify gadolinium plaque enhancement.

MATERIALS AND METHODS: Patients with stroke due to intracranial atherosclerotic disease underwent 7T high-resolution MR imaging. 3D segmentations of the plaque and its parent vessel were generated. Signal intensity probes were automatically extended from the lumen into the plaque and the vessel wall to generate 3D enhancement color maps. Plaque gadolinium (Gd) uptake was quantified from 3D color maps as gadolinium uptake = (µPlaque T1 + Gd −µPlaque T1/SDPlaque T1). Additional metrics of enhancement such as enhancement ratio, variance, and plaque-versus-parent vessel enhancement were also calculated. Conventional 2D measures of enhancement were collected for comparison.

RESULTS: Thirty-six culprit and 44 nonculprit plaques from 36 patients were analyzed. Culprit plaques had higher gadolinium uptake than nonculprit plaques ( P  &lt; .001). Gadolinium uptake was the most accurate metric for identifying culprit plaques (OR, 3.9; 95% CI 2.1–8.3). Gadolinium uptake was more sensitive (86% versus 70%) and specific (71% versus 68%) in identifying culprit plaques than conventional 2D measurements. A multivariate model, including gadolinium uptake and plaque burden, identified culprit plaques with an 83% sensitivity and 86% specificity.

CONCLUSIONS: The new 3D color map method of plaque-enhancement analysis is more accurate for identifying culprit plaques than conventional 2D methods. This new method generates a new set of metrics that could potentially be used to assess disease progression.

Gd
:   gadolinium
HR
:   high-resolution
ICAD
:   intracranial atherosclerotic disease
IPH
:   intraplaque hemorrhage
PB
:   plaque burden
RI
:   remodeling index
SI
:   signal intensity" />
<meta name="DC.Contributor" content="S. Sanchez" />
<meta name="DC.Contributor" content="A. Raghuram" />
<meta name="DC.Contributor" content="R. Fakih" />
<meta name="DC.Contributor" content="L. Wendt" />
<meta name="DC.Contributor" content="G. Bathla" />
<meta name="DC.Contributor" content="M. Hickerson" />
<meta name="DC.Contributor" content="S. Ortega-Gutierrez" />
<meta name="DC.Contributor" content="E. Leira" />
<meta name="DC.Contributor" content="E.A. Samaniego" />
<meta name="article:published_time" content="2022-09-01" />
<meta name="article:section" content="Adult Brain" />
<meta name="citation_title" content="3D Enhancement Color Maps in the Characterization of Intracranial Atherosclerotic Plaques" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;High-resolution MR imaging allows the identification of culprit symptomatic plaques after the administration of gadolinium. Current high-resolution MR imaging methods are limited by 2D multiplanar views and manual sampling of ROIs. We analyzed a new 3D method to objectively quantify gadolinium plaque enhancement.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Patients with stroke due to intracranial atherosclerotic disease underwent 7T high-resolution MR imaging. 3D segmentations of the plaque and its parent vessel were generated. Signal intensity probes were automatically extended from the lumen into the plaque and the vessel wall to generate 3D enhancement color maps. Plaque gadolinium (Gd) uptake was quantified from 3D color maps as gadolinium uptake = (µ&lt;sub&gt;Plaque T1 + Gd&lt;/sub&gt; −µ&lt;sub&gt;Plaque T1&lt;/sub&gt;/SD&lt;sub&gt;Plaque T1&lt;/sub&gt;). Additional metrics of enhancement such as enhancement ratio, variance, and plaque-versus-parent vessel enhancement were also calculated. Conventional 2D measures of enhancement were collected for comparison.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Thirty-six culprit and 44 nonculprit plaques from 36 patients were analyzed. Culprit plaques had higher gadolinium uptake than nonculprit plaques (&lt;i&gt;P &lt;/i&gt;&amp;lt; .001). Gadolinium uptake was the most accurate metric for identifying culprit plaques (OR, 3.9; 95% CI 2.1–8.3). Gadolinium uptake was more sensitive (86% versus 70%) and specific (71% versus 68%) in identifying culprit plaques than conventional 2D measurements. A multivariate model, including gadolinium uptake and plaque burden, identified culprit plaques with an 83% sensitivity and 86% specificity.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;The new 3D color map method of plaque-enhancement analysis is more accurate for identifying culprit plaques than conventional 2D methods. This new method generates a new set of metrics that could potentially be used to assess disease progression.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2022/09/01" />
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<meta name="citation_author" content="S. Sanchez" />
<meta name="citation_author_institution" content="aFrom the Department of Neurology (S.S., A.R., R.F., M.H., S.O.-G., E.L., E.A.S.)" />
<meta name="citation_author_orcid" content="https://orcid.org/0000-0003-4794-5717" />
<meta name="citation_author" content="A. Raghuram" />
<meta name="citation_author_institution" content="aFrom the Department of Neurology (S.S., A.R., R.F., M.H., S.O.-G., E.L., E.A.S.)" />
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<meta name="citation_reference" content="citation_journal_title=J Am Heart Assoc;citation_author=A. Gupta;citation_author=H. Baradaran;citation_author=K. Al-Dasuqi;citation_title=Gadolinium enhancement in intracranial atherosclerotic plaque and ischemic stroke: a systematic review and meta-analysis;citation_volume=5;citation_year=2016;citation_pmid=27528408;citation_doi=10.1161/JAHA.116.003816" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=A. Millon;citation_author=L. Boussel;citation_author=M. Brevet;citation_title=Clinical and histological significance of gadolinium enhancement in carotid atherosclerotic plaque;citation_volume=43;citation_year=2012;citation_pmid=22923447;citation_doi=10.1161/STROKEAHA.112.662692" />
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<meta name="citation_reference" content="citation_journal_title=International Journal of Stroke;citation_journal_abbrev=Int J Stroke;citation_author=J. Gutierrez;citation_author=MS. Elkind;citation_author=R. Virmani;citation_title=A Pathological Perspective on the Natural History of Cerebral Atherosclerosis;citation_pages=1074-1080;citation_volume=10;citation_year=2015;citation_issue=7;citation_pmid=25854637;citation_doi=10.1111/ijs.12496" />
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<meta name="citation_reference" content="citation_journal_title=Stroke;citation_journal_abbrev=Stroke;citation_author=HP. Adams;citation_author=BH. Bendixen;citation_author=LJ. Kappelle;citation_title=Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment;citation_pages=35-41;citation_volume=24;citation_year=1993;citation_issue=1;citation_pmid=7678184;citation_doi=10.1161/01.STR.24.1.35" />
<meta name="citation_reference" content="citation_journal_title=Cerebrovasc Dis;citation_author=P. Amarenco;citation_author=J. Bogousslavsky;citation_author=LR. Caplan;citation_title=The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping);citation_pages=1-5;citation_volume=36;citation_year=2013;citation_pmid=23899749;citation_doi=10.1159/000352050" />
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<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=Y. Qiao;citation_author=Z. Anwar;citation_author=J. Intrapiromkul;citation_title=Patterns and implications of intracranial arterial remodeling in stroke patients;citation_volume=47;citation_year=2016;citation_pmid=26742795;citation_doi=10.1161/STROKEAHA.115.009955" />
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<meta name="citation_reference" content="citation_journal_title=Journal of Neuroimaging;citation_journal_abbrev=J Neuroimaging;citation_author=TN. Turan;citation_author=L. Bonilha;citation_author=PS. Morgan;citation_title=Intraplaque hemorrhage in symptomatic intracranial atherosclerotic disease.;citation_pages=e159-e161;citation_volume=21;citation_year=2011;citation_issue=2;citation_pmid=19909397;citation_doi=10.1111/j.1552-6569.2009.00442.x" />
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<meta name="citation_reference" content="citation_journal_title=Magnetic resonance imaging;citation_journal_abbrev=Magn Reson Imaging;citation_author=A. Fedorov;citation_author=R. Beichel;citation_author=J. Kalpathy-Cramer;citation_title=3D Slicer as an image computing platform for the Quantitative Imaging Network.;citation_pages=1323-1341;citation_volume=30;citation_year=2012;citation_issue=9;citation_pmid=22770690;citation_doi=10.1016/j.mri.2012.05.001" />
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<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=Z. Shi;citation_author=J. Li;citation_author=M. Zhao;citation_title=Quantitative histogram analysis on intracranial atherosclerotic plaques: a high-resolution magnetic resonance imaging study;citation_pages=2161-69;citation_volume=51;citation_year=2020;citation_pmid=32568660;citation_doi=10.1161/STROKEAHA.120.029062" />
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<meta name="citation_reference" content="citation_journal_title=Atherosclerosis;citation_author=Y. Wang;citation_author=X. Liu;citation_author=X. Wu;citation_title=Culprit intracranial plaque without substantial stenosis in acute ischemic stroke on vessel wall MRI: a systematic review;citation_pages=112-21;citation_volume=287;citation_year=2019;citation_pmid=31254918;citation_doi=10.1016/j.atherosclerosis.2019.06.907" />
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<meta name="twitter:title" content="3D Enhancement Color Maps in the Characterization of Intracranial Atherosclerotic Plaques" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: High-resolution MR imaging allows the identification of culprit symptomatic plaques after the administration of gadolinium. Current high-resolution MR imaging methods are limited by 2D multiplanar views and manual sampling of ROIs. We analyzed a new 3D method to objectively quantify gadolinium plaque enhancement.

MATERIALS AND METHODS: Patients with stroke due to intracranial atherosclerotic disease underwent 7T high-resolution MR imaging. 3D segmentations of the plaque and its parent vessel were generated. Signal intensity probes were automatically extended from the lumen into the plaque and the vessel wall to generate 3D enhancement color maps. Plaque gadolinium (Gd) uptake was quantified from 3D color maps as gadolinium uptake = (µPlaque T1 + Gd −µPlaque T1/SDPlaque T1). Additional metrics of enhancement such as enhancement ratio, variance, and plaque-versus-parent vessel enhancement were also calculated. Conventional 2D measures of enhancement were collected for comparison.

RESULTS: Thirty-six culprit and 44 nonculprit plaques from 36 patients were analyzed. Culprit plaques had higher gadolinium uptake than nonculprit plaques ( P  &lt; .001). Gadolinium uptake was the most accurate metric for identifying culprit plaques (OR, 3.9; 95% CI 2.1–8.3). Gadolinium uptake was more sensitive (86% versus 70%) and specific (71% versus 68%) in identifying culprit plaques than conventional 2D measurements. A multivariate model, including gadolinium uptake and plaque burden, identified culprit plaques with an 83% sensitivity and 86% specificity.

CONCLUSIONS: The new 3D color map method of plaque-enhancement analysis is more accurate for identifying culprit plaques than conventional 2D methods. This new method generates a new set of metrics that could potentially be used to assess disease progression.

Gd
:   gadolinium
HR
:   high-resolution
ICAD
:   intracranial atherosclerotic disease
IPH
:   intraplaque hemorrhage
PB
:   plaque burden
RI
:   remodeling index
SI
:   signal intensity" />
<meta name="og-title" property="og:title" content="3D Enhancement Color Maps in the Characterization of Intracranial Atherosclerotic Plaques" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/43/9/1252" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: High-resolution MR imaging allows the identification of culprit symptomatic plaques after the administration of gadolinium. Current high-resolution MR imaging methods are limited by 2D multiplanar views and manual sampling of ROIs. We analyzed a new 3D method to objectively quantify gadolinium plaque enhancement.

MATERIALS AND METHODS: Patients with stroke due to intracranial atherosclerotic disease underwent 7T high-resolution MR imaging. 3D segmentations of the plaque and its parent vessel were generated. Signal intensity probes were automatically extended from the lumen into the plaque and the vessel wall to generate 3D enhancement color maps. Plaque gadolinium (Gd) uptake was quantified from 3D color maps as gadolinium uptake = (µPlaque T1 + Gd −µPlaque T1/SDPlaque T1). Additional metrics of enhancement such as enhancement ratio, variance, and plaque-versus-parent vessel enhancement were also calculated. Conventional 2D measures of enhancement were collected for comparison.

RESULTS: Thirty-six culprit and 44 nonculprit plaques from 36 patients were analyzed. Culprit plaques had higher gadolinium uptake than nonculprit plaques ( P  &lt; .001). Gadolinium uptake was the most accurate metric for identifying culprit plaques (OR, 3.9; 95% CI 2.1–8.3). Gadolinium uptake was more sensitive (86% versus 70%) and specific (71% versus 68%) in identifying culprit plaques than conventional 2D measurements. A multivariate model, including gadolinium uptake and plaque burden, identified culprit plaques with an 83% sensitivity and 86% specificity.

CONCLUSIONS: The new 3D color map method of plaque-enhancement analysis is more accurate for identifying culprit plaques than conventional 2D methods. This new method generates a new set of metrics that could potentially be used to assess disease progression.

Gd
:   gadolinium
HR
:   high-resolution
ICAD
:   intracranial atherosclerotic disease
IPH
:   intraplaque hemorrhage
PB
:   plaque burden
RI
:   remodeling index
SI
:   signal intensity" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node98739--5" data-node-nid="98739" id="top-node-98739--6943620154" data-pisa="ajnr;43/9/1252" data-pisa-master="ajnr;ajnr.A7605" data-apath="/ajnr/43/9/1252.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Adult Brain</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">3D Enhancement Color Maps in the Characterization of Intracranial Atherosclerotic Plaques</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">S. Sanchez</span>, <span class="highwire-citation-author" data-delta="1">A. Raghuram</span>, <span class="highwire-citation-author" data-delta="2">R. Fakih</span>, <span class="highwire-citation-author" data-delta="3">L. Wendt</span>, <span class="highwire-citation-author" data-delta="4">G. Bathla</span>, <span class="highwire-citation-author" data-delta="5">M. Hickerson</span>, <span class="highwire-citation-author" data-delta="6">S. Ortega-Gutierrez</span>, <span class="highwire-citation-author" data-delta="7">E. Leira</span> and <span class="highwire-citation-author" data-delta="8">E.A. Samaniego</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2022,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">43 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1252-1258; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A7605 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-98739--6943620154" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">S. Sanchez </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurology (S.S., A.R., R.F., M.H., S.O.-G., E.L., E.A.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BSanchez%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sanchez%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BSanchez%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4794-5717" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Sanchez</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">A. Raghuram </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurology (S.S., A.R., R.F., M.H., S.O.-G., E.L., E.A.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BRaghuram%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Raghuram%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BRaghuram%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8205-0527" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Raghuram</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">R. Fakih </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurology (S.S., A.R., R.F., M.H., S.O.-G., E.L., E.A.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BFakih%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Fakih%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.%2BFakih%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-9147-1737" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R. Fakih</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">L. Wendt </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Institute for Clinical and Translational Science (L.W.), University of Iowa, Iowa City, Iowa</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.%2BWendt%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wendt%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AL.%2BWendt%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1832-0486" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for L. Wendt</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">G. Bathla </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Radiology (G.B., S.O.-G., E.A.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BBathla%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bathla%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AG.%2BBathla%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-3170-242X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for G. Bathla</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">M. Hickerson </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurology (S.S., A.R., R.F., M.H., S.O.-G., E.L., E.A.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BHickerson%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hickerson%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BHickerson%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6337-506X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Hickerson</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">S. Ortega-Gutierrez </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurology (S.S., A.R., R.F., M.H., S.O.-G., E.L., E.A.S.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Radiology (G.B., S.O.-G., E.A.S.)</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Neurosurgery (S.O.-G., E.A.S.), University of Iowa Hospitals and Clinics, Iowa City, Iowa</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BOrtega-Gutierrez%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ortega-Gutierrez%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BOrtega-Gutierrez%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-3408-1297" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. 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Leira </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurology (S.S., A.R., R.F., M.H., S.O.-G., E.L., E.A.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BLeira%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Leira%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AE.%2BLeira%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-3695-2946" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for E. 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Samaniego </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurology (S.S., A.R., R.F., M.H., S.O.-G., E.L., E.A.S.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Radiology (G.B., S.O.-G., E.A.S.)</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Neurosurgery (S.O.-G., E.A.S.), University of Iowa Hospitals and Clinics, Iowa City, Iowa</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.A.%2BSamaniego%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Samaniego%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AE.A.%2BSamaniego%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2764-2268" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for E.A. 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 43</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 9 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Sep 2022 </div></div>
      
      
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