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<meta name="DC.Description" content="SUMMARY: In 2021, the World Health Organization released an updated classification of CNS tumors. This update reflects the growing understanding of the importance of genetic alterations related to tumor pathogenesis, prognosis, and potential targeted treatments and introduces 22 newly recognized tumor types. Herein, we review these 22 newly recognized entities and emphasize their imaging appearance with correlation to histologic and genetic features.

AT/RT
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cIMPACT-NOW
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&lt;p&gt;In 2021, the World Health Organization released an updated classification of CNS tumors. This update reflects the growing understanding of the importance of genetic alterations related to tumor pathogenesis, prognosis, and potential targeted treatments and introduces 22 newly recognized tumor types. Herein, we review these 22 newly recognized entities and emphasize their imaging appearance with correlation to histologic and genetic features.&lt;/p&gt;" />
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<meta name="twitter:title" content="Newly Recognized CNS Tumors in the 2021 World Health Organization Classification: Imaging Overview with Histopathologic and Genetic Correlation" />
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<meta name="twitter:description" content="SUMMARY: In 2021, the World Health Organization released an updated classification of CNS tumors. This update reflects the growing understanding of the importance of genetic alterations related to tumor pathogenesis, prognosis, and potential targeted treatments and introduces 22 newly recognized tumor types. Herein, we review these 22 newly recognized entities and emphasize their imaging appearance with correlation to histologic and genetic features.

AT/RT
:   atypical teratoid/rhabdoid tumor
cIMPACT-NOW
:   Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-Not Official WHO
GFAP
:   glial fibrillary acidic protein
MAPK
:   mitogen-activated protein kinase
NEC
:   not elsewhere classified
NOS
:   not otherwise specified
PFA and PFB
:   posterior fossa ependymoma groups A and B
WHO
:   World Health Organization
WHO CNS5
:   World Health Organization Classification of Tumors of the Central Nervous System , fifth edition
IDH
:   isocitrate dehydrogenase" />
<meta name="og-title" property="og:title" content="Newly Recognized CNS Tumors in the 2021 World Health Organization Classification: Imaging Overview with Histopathologic and Genetic Correlation" />
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<meta name="og-description" property="og:description" content="SUMMARY: In 2021, the World Health Organization released an updated classification of CNS tumors. This update reflects the growing understanding of the importance of genetic alterations related to tumor pathogenesis, prognosis, and potential targeted treatments and introduces 22 newly recognized tumor types. Herein, we review these 22 newly recognized entities and emphasize their imaging appearance with correlation to histologic and genetic features.

AT/RT
:   atypical teratoid/rhabdoid tumor
cIMPACT-NOW
:   Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-Not Official WHO
GFAP
:   glial fibrillary acidic protein
MAPK
:   mitogen-activated protein kinase
NEC
:   not elsewhere classified
NOS
:   not otherwise specified
PFA and PFB
:   posterior fossa ependymoma groups A and B
WHO
:   World Health Organization
WHO CNS5
:   World Health Organization Classification of Tumors of the Central Nervous System , fifth edition
IDH
:   isocitrate dehydrogenase" />
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      <h1 class="highwire-cite-title" id="page-title">Newly Recognized CNS Tumors in the 2021 World Health Organization Classification: Imaging Overview with Histopathologic and Genetic Correlation</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">R.K. Rigsby</span>, <span class="highwire-citation-author" data-delta="1">P. Brahmbhatt</span>, <span class="highwire-citation-author" data-delta="2">A.B. Desai</span>, <span class="highwire-citation-author" data-delta="3">G. Bathla</span>, <span class="highwire-citation-author" data-delta="4">B.A. Ebner</span>, <span class="highwire-citation-author" data-delta="5">V. Gupta</span>, <span class="highwire-citation-author" data-delta="6">P. Vibhute</span> and <span class="highwire-citation-author" data-delta="7">A.K. Agarwal</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">March 2023,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A7827 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-101888--61698503931" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">R.K. Rigsby </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (R.K.R., P.B., A.B.D., V.G., P.V., A.K.A.), Mayo Clinic, Jacksonville, Florida</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.K.%2BRigsby%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rigsby%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.K.%2BRigsby%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6347-7012" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R.K. Rigsby</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">P. Brahmbhatt </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (R.K.R., P.B., A.B.D., V.G., P.V., A.K.A.), Mayo Clinic, Jacksonville, Florida</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BBrahmbhatt%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Brahmbhatt%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AP.%2BBrahmbhatt%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-5600-441X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for P. Brahmbhatt</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A.B. Desai </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (R.K.R., P.B., A.B.D., V.G., P.V., A.K.A.), Mayo Clinic, Jacksonville, Florida</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.B.%2BDesai%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Desai%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.B.%2BDesai%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-3073-6823" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.B. Desai</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">G. Bathla </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Radiology (G.B.), Mayo Clinic, Rochester, Minnesota</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BBathla%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bathla%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AG.%2BBathla%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-3170-242X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for G. 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Gupta </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (R.K.R., P.B., A.B.D., V.G., P.V., A.K.A.), Mayo Clinic, Jacksonville, Florida</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=V.%2BGupta%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gupta%20V&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AV.%2BGupta%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-4298-7179" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for V. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">R.K. Rigsby</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">P. Brahmbhatt</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-3"><span class="name">A.B. Desai</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-4"><span class="name">G. Bathla</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-5"><span class="name">B.A. Ebner</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-6"><span class="name">V. Gupta</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-7"><span class="name">P. Vibhute</span><a id="xref-aff-1-5" class="xref-aff" href="#aff-1">a</a> and </li><li class="last" id="contrib-8"><span class="name">A.K. Agarwal</span><a id="xref-aff-1-6" class="xref-aff" href="#aff-1">a</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Department of Radiology (R.K.R., P.B., A.B.D., V.G., P.V., A.K.A.), Mayo Clinic, Jacksonville, Florida</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>Department of Radiology (G.B.), Mayo Clinic, Rochester, Minnesota</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>c</sup>Department of Laboratory Medicine and Pathology (B.A.E.), Mayo Clinic, Rochester, Minnesota</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Please address correspondence to Amit K. Agarwal, MBBS, MD, <span class="addr-line">Department of Radiology, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL 32224</span>; e-mail: <span class="em-link"><span class="em-addr">Agarwal.Amit{at}mayo.edu</span></span></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/early/2023/03/30/ajnr.A7827.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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