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<meta name="DC.Title" content="Thalamic Projection Fiber Integrity in de novo Parkinson Disease" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3178" />
<meta name="DC.Date" content="2012-07-05" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Postmortem studies of advanced PD have revealed disease-related pathology in the thalamus with an apparent predilection for specific thalamic nuclei. In the present study, we used DTI to investigate in vivo the microstructural integrity of 6 thalamic regions in de novo patients with PD relative to healthy controls.

MATERIALS AND METHODS: Forty subjects (20 with early stage untreated PD and 20 age- and sex-matched controls) were studied with a high-resolution DTI protocol at 3T to investigate the integrity of thalamic nuclei projection fibers. Two blinded, independent raters drew ROIs in the following 6 thalamic regions: AN, VA, VL, DM, VPL/VPM, and PU. FA values were then calculated from the projection fibers in each region.

RESULTS: FA values were reduced significantly in the fibers projecting from the AN, VA, and DM, but not the VPL/VPM and PU, in the PD group compared with the control group. In addition, there was a reduction in FA values that approached significance in the VL of patients with PD. These findings were consistent across both raters.

CONCLUSIONS: The present study provides preliminary in vivo evidence of thalamic projection fiber degeneration in de novo PD and sheds light on the extent of disrupted thalamic circuitry as a result of the disease itself.

### Abbreviations

AN
:   anterior nucleus
DM
:   dorsomedial nucleus
FA
:   fractional anisotropy
PD
:   Parkinson disease
PU
:   pulvinar
SN
:   substantia nigra
VA
:   ventral anterior nucleus
VL
:   ventral lateral nucleus
VPL
:   ventral posterior lateral nucleus
VPM
:   ventral posterior medial nucleus" />
<meta name="DC.Contributor" content="P.J. Planetta" />
<meta name="DC.Contributor" content="E.T. Schulze" />
<meta name="DC.Contributor" content="E.K. Geary" />
<meta name="DC.Contributor" content="D.M. Corcos" />
<meta name="DC.Contributor" content="J.G. Goldman" />
<meta name="DC.Contributor" content="D.M. Little" />
<meta name="DC.Contributor" content="D.E. Vaillancourt" />
<meta name="article:published_time" content="2012-07-05" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Thalamic Projection Fiber Integrity in de novo Parkinson Disease" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Postmortem studies of advanced PD have revealed disease-related pathology in the thalamus with an apparent predilection for specific thalamic nuclei. In the present study, we used DTI to investigate in vivo the microstructural integrity of 6 thalamic regions in de novo patients with PD relative to healthy controls.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Forty subjects (20 with early stage untreated PD and 20 age- and sex-matched controls) were studied with a high-resolution DTI protocol at 3T to investigate the integrity of thalamic nuclei projection fibers. Two blinded, independent raters drew ROIs in the following 6 thalamic regions: AN, VA, VL, DM, VPL/VPM, and PU. FA values were then calculated from the projection fibers in each region.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;FA values were reduced significantly in the fibers projecting from the AN, VA, and DM, but not the VPL/VPM and PU, in the PD group compared with the control group. In addition, there was a reduction in FA values that approached significance in the VL of patients with PD. These findings were consistent across both raters.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;The present study provides preliminary in vivo evidence of thalamic projection fiber degeneration in de novo PD and sheds light on the extent of disrupted thalamic circuitry as a result of the disease itself.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_article_type" content="Research Article" />
<meta name="citation_section" content="BRAIN" />
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<meta name="citation_author" content="P.J. Planetta" />
<meta name="citation_author" content="E.T. Schulze" />
<meta name="citation_author" content="E.K. Geary" />
<meta name="citation_author" content="D.M. Corcos" />
<meta name="citation_author" content="J.G. Goldman" />
<meta name="citation_author" content="D.M. Little" />
<meta name="citation_author" content="D.E. Vaillancourt" />
<meta name="citation_fulltext_world_readable" content="" />
<meta name="twitter:title" content="Thalamic Projection Fiber Integrity in de novo Parkinson Disease" />
<meta name="twitter:card" content="summary" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Postmortem studies of advanced PD have revealed disease-related pathology in the thalamus with an apparent predilection for specific thalamic nuclei. In the present study, we used DTI to investigate in vivo the microstructural integrity of 6 thalamic regions in de novo patients with PD relative to healthy controls.

MATERIALS AND METHODS: Forty subjects (20 with early stage untreated PD and 20 age- and sex-matched controls) were studied with a high-resolution DTI protocol at 3T to investigate the integrity of thalamic nuclei projection fibers. Two blinded, independent raters drew ROIs in the following 6 thalamic regions: AN, VA, VL, DM, VPL/VPM, and PU. FA values were then calculated from the projection fibers in each region.

RESULTS: FA values were reduced significantly in the fibers projecting from the AN, VA, and DM, but not the VPL/VPM and PU, in the PD group compared with the control group. In addition, there was a reduction in FA values that approached significance in the VL of patients with PD. These findings were consistent across both raters.

CONCLUSIONS: The present study provides preliminary in vivo evidence of thalamic projection fiber degeneration in de novo PD and sheds light on the extent of disrupted thalamic circuitry as a result of the disease itself.

### Abbreviations

AN
:   anterior nucleus
DM
:   dorsomedial nucleus
FA
:   fractional anisotropy
PD
:   Parkinson disease
PU
:   pulvinar
SN
:   substantia nigra
VA
:   ventral anterior nucleus
VL
:   ventral lateral nucleus
VPL
:   ventral posterior lateral nucleus
VPM
:   ventral posterior medial nucleus" />
<meta name="og-title" property="og:title" content="Thalamic Projection Fiber Integrity in de novo Parkinson Disease" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/early/2012/07/05/ajnr.A3178" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Postmortem studies of advanced PD have revealed disease-related pathology in the thalamus with an apparent predilection for specific thalamic nuclei. In the present study, we used DTI to investigate in vivo the microstructural integrity of 6 thalamic regions in de novo patients with PD relative to healthy controls.

MATERIALS AND METHODS: Forty subjects (20 with early stage untreated PD and 20 age- and sex-matched controls) were studied with a high-resolution DTI protocol at 3T to investigate the integrity of thalamic nuclei projection fibers. Two blinded, independent raters drew ROIs in the following 6 thalamic regions: AN, VA, VL, DM, VPL/VPM, and PU. FA values were then calculated from the projection fibers in each region.

RESULTS: FA values were reduced significantly in the fibers projecting from the AN, VA, and DM, but not the VPL/VPM and PU, in the PD group compared with the control group. In addition, there was a reduction in FA values that approached significance in the VL of patients with PD. These findings were consistent across both raters.

CONCLUSIONS: The present study provides preliminary in vivo evidence of thalamic projection fiber degeneration in de novo PD and sheds light on the extent of disrupted thalamic circuitry as a result of the disease itself.

### Abbreviations

AN
:   anterior nucleus
DM
:   dorsomedial nucleus
FA
:   fractional anisotropy
PD
:   Parkinson disease
PU
:   pulvinar
SN
:   substantia nigra
VA
:   ventral anterior nucleus
VL
:   ventral lateral nucleus
VPL
:   ventral posterior lateral nucleus
VPM
:   ventral posterior medial nucleus" />
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      <h1 class="highwire-cite-title" id="page-title">Thalamic Projection Fiber Integrity in de novo Parkinson Disease</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">P.J. Planetta</span>, <span class="highwire-citation-author" data-delta="1">E.T. Schulze</span>, <span class="highwire-citation-author" data-delta="2">E.K. Geary</span>, <span class="highwire-citation-author" data-delta="3">D.M. Corcos</span>, <span class="highwire-citation-author" data-delta="4">J.G. Goldman</span>, <span class="highwire-citation-author" data-delta="5">D.M. Little</span> and <span class="highwire-citation-author" data-delta="6">D.E. Vaillancourt</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">July 2012,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3178 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-49826--82024224389" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">P.J. Planetta </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.J.%2BPlanetta%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Planetta%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AP.J.%2BPlanetta%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">E.T. 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